verb (used with object), estranged, estranging.
to turn away in feeling or affection; make unfriendly or hostile; alienate the affections of: Their quarrel estranged the two friends.
to remove to or keep at a distance: The necessity for traveling on business has estranged him from his family.
to divert from the original use or possessor.

1475–85; < Middle French, Old French estranger; cognate with Portuguese estranhar, Spanish estrañar, Italian straniare < Medieval Latin exstrāneāre to treat as a stranger. See strange

estrangement, noun
estranger, noun
self-estrangement, noun

Estrange, alienate, disaffect share the sense of causing (someone) to turn away from a previously held state of affection, comradeship, or allegiance. Estrange often implies replacement of love or belonging by apathy or hostility: erstwhile lovers estranged by a misunderstanding. Alienate often calls attention to the cause of antagonism or separation: His inconsiderate behavior alienated both friends and family. Disaffect usually refers to relationships involving allegiance or loyalty rather than love or affection: disaffected workers, demoralized by ill-considered management policies. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
estrange (ɪˈstreɪndʒ)
vb (often foll by from) (often foll by from)
1.  to separate and live apart from (one's spouse): he is estranged from his wife
2.  to antagonize or lose the affection of (someone previously friendly); alienate
[C15: from Old French estranger, from Late Latin extrāneāre to treat as a stranger, from Latin extrāneus foreign; see strange]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

late 15c., from M.Fr. estrangier "alienate," from L. extraneus "foreign" (see strange). Related: Estranged; estrangement.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
It could be called encampment, or maybe estrangement.
But his estrangement from the drafting table didn't last long.
Then they talked for hours, crying over their estrangement.
Above all, it shows how the photographer projected her inner torment and sense
  of estrangement onto her unsuspecting sitters.
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