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early 15c., from Middle French orifice "the opening of a wound" (14c.) and directly from Latin orificium "an opening," literally "mouth-making," from os (genitive oris) "mouth" (see oral) + facere "make" (see factitious). Related: Orificial.
orifice or·i·fice (ôr'ə-fĭs)n. An opening, especially to a cavity or passage of the body; a mouth or vent.