woe unto the world because of offenses; for it must needs be that offenses come, but woe to that man by whom the offense cometh.
Theodore Roethke wrote, “I have myself an inner weight of woe/ That God himself can scarcely bear.”
There's UP and US, and UT—an old name for the first (and last) tone, do, and WE (the funnest pronoun) and WO, which is woe.
Old English wa, a common exclamation of lament in many languages (cf. Latin væ, Greek oa, German weh, Lettish wai, Old Irish fe, Welsh gwae, Armenian vay). The noun is attested from late 12c., from the interjection.