

2.
Leave, depart, especially suddenly, as in Don't go off mad, or They went off without saying goodbye. [c. 1600]
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Keep to the expected plan or course of events, succeed, as in The project went off smoothly. [Second half of 1700s]
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Deteriorate in quality, as in This milk seems to have gone off. [Late 1600s]
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Die. Shakespeare used this sense in Macbeth (5:9): "I would the friends we missed were safely arrived.
Some must go off." -
Experience orgasm. D.H. Lawrence used this slangy sense in Lady Chatterley's Lover (1928): "You couldn't go off at the same time...." This usage is probably rare today. Also see get off, def. 8.
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go off on a tangent. See under on a tangent.
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go off one's head. See off one's head. Also see subsequent idioms beginning with go off.
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