disease characterized by the deposition of amyloid in the connective tissues and organs, inhibiting normal functioning. Amyloid is a fibrous protein-carbohydrate complex that is derived from immunoglobulins, a group of proteins that have antibody activity. The disease may affect the whole system or may be localized in tumourlike masses, particularly in the larynx or in some other portion of the upper respiratory tract. The localized form of amyloidosis is primary-unassociated with any other disease. The systemic form of the disease may be primary or associated with a chronic disease such as tuberculosis, syphilis, or rheumatoid arthritis. There is no treatment for primary systemic amyloidosis; treatment for secondary systemic amyloidosis is directed toward reducing the harmful effects of the disease on the organs. The localized form of the disease may be treated by surgical removal of amyloidic masses
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