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The defeat of Colonel George A. Custer and his cavalry detachment by a large force of Native Americans at the Battle of the Little Bighorn in 1876. Custer had been pursuing a group of Sioux, led by Sitting Bull, who had risen in arms against settlement of the country. Custer foolishly underestimated the size and ability of the Sioux forces, who were supported by Cheyenne warriors. Custer and all of the soldiers in his column were killed.