to turn away in feeling or affection; make unfriendly or hostile; alienate the affections of: Their quarrel estranged the two friends.
2.
to remove to or keep at a distance: The necessity for traveling on business has estranged him from his family.
3.
to divert from the original use or possessor.
Origin: 1475–85; < MF, OF estranger; c. Pg estranhar, Sp estrañar, It straniare < ML exstrāneāre to treat as a stranger. See strange
Related forms:
es⋅trange⋅ment, noun
es⋅trang⋅er, noun
Synonyms: Estrange,alienate,disaffect share the sense of causing (someone) to turn away from a previously held state of affection, comradeship, or allegiance. Estrange often implies replacement of love or belonging by apathy or hostility: erstwhile lovers estranged by a misunderstanding. Alienate often calls attention to the cause of antagonism or separation: His inconsiderate behavior alienated both friends and family. Disaffect usually refers to relationships involving allegiance or loyalty rather than love or affection: disaffected workers, demoralized by ill-considered management policies.
To make hostile, unsympathetic, or indifferent; alienate.
To remove from an accustomed place or set of associations.
[Middle English estraungen, from Old French estrangier, from Latin extrāneāre, to treat as a stranger, disown, from extrāneus, foreign; see strange.] es·trange'ment n., es·trang'er n.
Synonyms: These verbs refer to disruption of a bond of love, friendship, or loyalty. Estrange and alienate are often used with reference to two persons whose harmonious relationship has been replaced by hostility or indifference: Political disagreements led to quarrels that finally estranged the two friends. His persistent antagonism alienated his wife. Disaffect usually implies discontent, ill will, and disloyalty within the membership of a group: Colonists were disaffected by the royal governor's actions.
[i-streynj] 
