to inflict severe pain upon; torture: The headache excruciated him.
2.
to cause mental anguish to; irritate greatly.
Origin: 1560–70; < L excruciātus, ptp. of excruciāre to torment, torture, equiv. to ex-ex-1+ cruciāre to torment, crucify (deriv. of crux cross); see ate1
1570, from L. excruciatus, pp. of excruciare "to torture, torment," from ex- "out, thoroughly" + cruciare "cause pain or anguish to," lit. "crucify," from crux (gen. crucis) "cross."