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large estate-named for its original building, a "large barn"-established in 1657 on the slopes of Devil's Peak directly southeast of Cape Town, S.Af. After undergoing numerous subdivisions and changes of ownership, the estate was acquired in 1891 and enlarged by Cecil Rhodes, who bequeathed it to South Africa in 1902. It is the site of a zoo and game reserve, the Rhodes Memorial, and the campus of the University of Cape Town and its affiliated hospital (also named Groote Schuur), where in 1967 the first human-heart transplant was performed. The restored Groote Schuur was formerly the official Cape Town residence of the prime minister of South Africa; Westbrooke, another mansion on the estate, is now the residence of the prime minister.