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guinea pig

noun
1.
a short-eared, tailless rodent of the genus Cavia, usually white, black, and tawny, commonly regarded as the domesticated form of one of the South American wild species of cavy: often used in scientific experiments or kept as a pet.
2.
Informal. the subject of any sort of experiment.
Origin
1655-1665
1655-65
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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British Dictionary definitions for guinea pigs

guinea pig

noun
1.
a domesticated cavy, probably descended from Cavia porcellus, commonly kept as a pet and used in scientific experiments
2.
a person or thing used for experimentation
Word Origin
C17: origin uncertain: perhaps from old use of the name Guinea to mean any remote unknown land
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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Word Origin and History for guinea pigs

guinea pig

1660s, native to South America and perhaps so called either because it was first brought back to Britain aboard Guinea-men, ships that plied the triangle trade between England, Guinea, and South America [Barnhart, Klein]; or from confusion of Guinea (q.v.) with the South American region of Guyana (but OED is against this). In the extended sense of "one subjected to an experiment" it is first recorded 1920, because they were commonly used in vivisection experiments.

Online Etymology Dictionary, © 2010 Douglas Harper
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guinea pigs in Medicine

guinea pig guin·ea pig (gĭn'ē)
n.
Any of various small, short-eared domesticated rodents of the genus Cavia, having variously colored hair and no visible tail. They are widely kept as pets and often used as experimental animals.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Slang definitions & phrases for guinea pigs

guinea pig

noun

Person or thing used in an experiment, sometimes without agreement: the guinea pigs for her cooking


The Dictionary of American Slang, Fourth Edition by Barbara Ann Kipfer, PhD. and Robert L. Chapman, Ph.D.
Copyright (C) 2007 by HarperCollins Publishers.
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Word Value for guinea

7
10
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