noun Slang.
a person from the same locality as oneself.
a close friend or fellow gang member.

1895–1900, Americanism;home + boy

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Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
homeboy (ˈhəʊmˌbɔɪ)
1.  a close friend
2.  a person from one's home town or neighbourhood
[C20: US rap-music usage]
fem n

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

"person from one's hometown," 1940s, Amer.Eng., black slang, also originally with overtones of "simpleton." With many variants (cf. homebuddy, homeslice, both 1980s, with meaning shading toward "good friend"). The word had been used by Ruskin (1886) with the sense "stay-at-home male," and it was Canadian
slang for "boy brought up in an orphanage or other institution" (1913). Short form homie attested by 1970s; in New Zealand slang this meant "English or British immigrant" (1927).
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Anybody who didn't know better would have thought homeboy was on the mend.
It does happen with some frequency that a gang member will testify against his fellow homeboy.
He goes against the grain to get even with that homeboy who slighted him.
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