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The city of this name mentioned in Scripture lay on the confines of Phrygia and Lydia, about 40 miles east of Ephesus (Rev. 3:14), on the banks of the Lycus. It was originally called Diospolis and then Rhoas, but afterwards Laodicea, from Laodice, the wife of Antiochus II., king of Syria, who rebuilt it. It was one of the most important and flourishing cities of Asia Minor. At a very early period it became one of the chief seats of Christianity (Col. 2:1; 4:15; Rev. 1:11, etc.). It is now a deserted place, called by the Turks Eski-hissar or "old castle."
the ancient name of several cities of western Asia, mostly founded or rebuilt in the 3rd century BC by rulers of the Seleucid dynasty, and named after Laodice, the mother of Seleucus I Nicator, or after Laodice, daughter (or possibly niece) of Antiochus I Soter and wife of Antiochus II Theos. Established as commercial centres on newly opened or reconditioned trade routes, or as strongholds for the pacification of parts of the Seleucid empire, the cities aided in the Hellenization of western Asia and subsequently in the spread of Christianity in the region