a combining form meaning “one trillionth” (10 −12 ): picogram.

< Spanish pico peak, beak, bit. See pic2

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World English Dictionary
p denoting 10--12: picofarad
[from Spanish pico small quantity, odd number, peak]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

1915, adopted c.1952 as a scientific prefix meaning "one trillionth," from Sp. pico "a little over, a small balance," lit. "sharp point, beak," of Celtic origin (cf. Gaul. beccus "beak"). Picosecond first recorded 1966.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

pico- pref.

  1. One-trillionth (10-12): picogram.

  2. Very small: picornavirus.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Abbreviations & Acronyms
Polio Information Center Online
The American Heritage® Abbreviations Dictionary, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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Example sentences
Pico projectors will eventually be incorporated and then laptop projectors will be largely gone.
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