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achondroplasia

[ey-kon-druh-pley-zhuh, -zhee-uh, -zee-uh] /eɪˌkɒn drəˈpleɪ ʒə, -ʒi ə, -zi ə/
noun, Pathology
1.
defective conversion of cartilage into bone, especially at the epiphyses of long bones, producing a type of dwarfism.
Origin
1890-1895
1890-95; a-6 + chondro- + -plasia
Related forms
achondroplastic
[ey-kon-druh-plas-tik] /eɪˌkɒn drəˈplæs tɪk/ (Show IPA),
adjective
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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British Dictionary definitions for achondroplasia

achondroplasia

/eɪˌkɒndrəʊˈpleɪzɪə/
noun
1.
a skeletal disorder, characterized by failure of normal conversion of cartilage into bone, that begins during fetal life and results in dwarfism
Derived Forms
achondroplastic (eɪˌkɒndrəʊˈplæstɪk) adjective
Word Origin
C20: New Latin; see a-1, chondro-, -plasia
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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achondroplasia in Medicine

achondroplasia a·chon·dro·pla·sia (ā-kŏn'drō-plā'zhə, -zhē-ə, ə-kŏn'-) or a·chon·dro·plas·ty (ā-kŏn'drō-plās'tē, ə-kŏn'-)
n.
Improper development of cartilage at the ends of the long bones, resulting in a form of congenital dwarfism. Also called osteosclerosis congenita.


a·chon'dro·plas'tic (-plās'tĭk) adj.
The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Article for achondroplasia

genetic disorder characterized by an abnormality in the conversion of cartilage into bone. As a consequence, bones that depend on cartilage models for development, particularly long bones such as the femur and humerus, cannot grow. Achondroplasia is the most common cause of dwarfism. In those afflicted with the disorder, the limbs are very short (fingers reach only to the hips), but the trunk is almost normal in size. The head is enlarged because of some overgrowth of the vault bones following premature closure of sutures at the base of the skull. Other manifestations of achrondoplasia include a bulging forehead, saddle nose, protruding jaw, deeply incurved lower back with prominent buttocks, and a narrow chest; women with the disorder may have narrow pelvises and, subsequently, difficulty in childbirth. Achondroplasia is inherited as an autosomal dominant trait; about 80 percent of cases of the disorder result from new genetic mutations rather than from the parental transmission of defective genes. Affected individuals are of normal intelligence and have otherwise normal health.

Learn more about achondroplasia with a free trial on Britannica.com
Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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