adrenogenital syndrome a·dre·no·gen·i·tal syndrome (ə-drē'nō-jěn'ĭ-tl)
A group of disorders caused by adrenocortical hyperplasia or malignant tumors, resulting in abnormal secretion of adrenocortical hormones and characterized by masculinization of women, feminization of men, or precocious sexual development in children.
enlargement of the adrenal glands resulting primarily from excessive secretion of androgenic hormones by the adrenal cortex. Congenital adrenal hyperplasia mainly affects infants and is caused by mutations in the genes for enzymes that catalyze the production of cortisol by the adrenal glands. As a result of decreased cortisol production, there is increased secretion of the anterior pituitary hormone corticotropin. The high levels of corticotropin may restore cortisol secretion to near normal; however, they also stimulate the production of androgen and sometimes mineralocorticoids (hormones that stimulate retention of salt and water by the kidneys) by the adrenal cortex.
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