an·ni·hi·la·tion

[uh-nahy-uh-ley-shuhn]
noun
1.
the act or an instance of annihilating.
2.
the state of being annihilated; extinction; destruction.
3.
Physics.
a.
Also called pair annihilation. the process in which a particle and antiparticle unite, annihilate each other, and produce one or more photons. Compare positronium.
b.
the conversion of rest mass into energy in the form of electromagnetic radiation.

Origin:
1630–40; (< F) < Late Latin annihilātiōn- (stem of annihilātiō). See annihilate, -ion

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World English Dictionary
annihilation (əˌnaɪəˈleɪʃən) [Click for IPA pronunciation guide]
 
n
1.  total destruction
2.  the act of annihilating
3.  physics the destruction of a particle and its antiparticle when they collide. The annihilation of an electron with a positron generates two or, very rarely, three photons of annihilation radiation. The annihilation of a nucleon with its antiparticle generates several pions

Collins English Dictionary - Complete & Unabridged 10th Edition
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00:10
Annihilation is always a great word to know.
So is quincunx. Does it mean:
an arrangement of five objects, as trees, in a square or rectangle, one at each corner and one in the middle.
the offspring of a zebra and a donkey.
Etymonline
Word Origin & History

annihilation
1630s, from Fr. annihilation, restored from O.Fr. anichilacion (14c.), from L.L. annihilare (see annihilate).
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Complete and utter annihilation by nuclear disaster and/or an asteroid
  collision with all of us on one planet was almost certain.
Suicide, self-destruction, auto-annihilation: these are not pretty words.
It's an unholy mix of encryption, anonymity, and digital cash to bring about
  the ultimate annihilation of all forms of government.
They faked auto-annihilation and worked underground on weaponry based on false
  vacuum.
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