[an-ti-his-tuh-meen, -min]
noun Physiology, Pharmacology.
any of certain compounds or medicines that neutralize or inhibit the effect of histamine in the body, used chiefly in the treatment of allergic disorders and colds.

1930–35; anti- + histamine Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
antihistamine (ˌæntɪˈhɪstəˌmiːn, -mɪn)
any drug that neutralizes the effects of histamine, used esp in the treatment of allergies

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

1933, from anti- + histamine, from histidine (from Gk. histion "web," dim. of histos "a loom, web," from histanai "to set up") + amine.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

antihistamine an·ti·his·ta·mine (ān'tē-hĭs'tə-mēn', -mĭn)
Any of several drugs used to counteract the physiological effects of histamine.

an'ti·his'ta·mine' adj.
The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
antihistamine   (ān'tē-hĭs'tə-mēn')  Pronunciation Key 
Any of various drugs that relieve cold or allergy symptoms by blocking the action of histamine.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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