[an-tee-di-pres-uhnt, an-tahy-] Pharmacology.
of or pertaining to a substance that is used in the treatment of mood disorders, as characterized by various manic or depressive affects.
Also called energizer, psychic energizer. any such substance, as a tricyclic antidepressant, MAO inhibitor, or lithium.
Also, anti-depressant, antidepressive [an-tee-di-pres-iv, an-tahy-] .

1960–65; anti- + depressant Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
antidepressant (ˌæntɪdɪˈprɛsənt)
1.  any of a class of drugs used to alleviate depression
2.  of or relating to this class of drugs

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

by 1959, from anti- + depress + adj. suffix -ant.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

antidepressant an·ti·de·pres·sant (ān'tē-dĭ-prěs'ənt, ān'tī-)
A drug used to prevent or relieve mental depression.

an'ti·de·pres'sive (-prěs'ĭv) adj.
The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
antidepressant   (ān'tē-dĭ-prěs'ənt, ān'tī-)  Pronunciation Key 
A drug used to prevent or treat depression.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Example sentences
My husband has been able to get off his antidepressant medication with the
  blessings of his doctor.
The use of antidepressant drugs are becoming equally common.
No wonder one of our break room topics is who is taking which antidepressant.
In other words, the brain's anticonvulsant mechanism may alter the brain's
  neurochemistry, acting as a built-in antidepressant.
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