Quiz: Remember the definition of mal de mer?
1580s, from Spanish tabaco, in part from an Arawakan (probably Taino) language of the Caribbean, said to mean "a roll of tobacco leaves" (according to Las Casas, 1552) or "a kind of pipe for smoking tobacco" (according to Oviedo, 1535). Scholars of Caribbean languages lean toward Las Casas' explanation. But Spanish tabaco (also Italian tabacco) was a name of medicinal herbs from early 15c., from Arabic tabbaq, attested since 9c. as the name of various herbs. So the word may be a European one transferred to an American plant. The West Indian island of Tobago was said to have been named by Columbus in 1498 from Haitian tambaku "pipe," in reference to the native custom of smoking dried tobacco leaves [Room].
Cultivation in France began 1556 with an importation of seed by Andre Thevet; introduced in Spain 1558 by Francisco Fernandes. Tobacco Road as a mythical place representative of rural Southern U.S. poverty is from the title of Erskine Caldwell's 1932 novel.