antroduodenectomy an·tro·du·o·de·nec·to·my (ān'trō-d&oomacr;'ō-dn-ěk'tə-mē, -dy&oomacr;'-, -d&oomacr;-ŏd'n-ěk'tə-mē, -dy&oomacr;-) n. Surgical removal of the antrum of the stomach and the ulcer-bearing part of the duodenum.