World English Dictionary
artefact or artifact (ˈɑːtɪˌfækt)
1.  something made or given shape by man, such as a tool or a work of art, esp an object of archaeological interest
2.  anything man-made, such as a spurious experimental result
3.  cytology a structure seen in tissue after death, fixation, staining, etc, that is not normally present in the living tissue
[C19: from Latin phrase arte factum, from ars skill + facere to make]
artifact or artifact
[C19: from Latin phrase arte factum, from ars skill + facere to make]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

alt. spelling of artifact (q.v.).
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

artefact ar·te·fact (är'tə-fākt')
Variant of artifact.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
artifact also artefact   (är'tə-fākt')  Pronunciation Key 
  1. An object produced or shaped by human craft, especially a tool, weapon, or ornament of archaeological or historical interest.

  2. An artificial product or effect observed in a natural system, especially one introduced by the technology used in scientific investigation or by experimental error.

The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Example sentences
Your student would have the option of specializing in paper, or artefacts, or
Below you'll see a beautiful set of photographs of the artefacts from the
  archaeological site.
If such notions are cultural artefacts, though, they will vary systematically
  with some aspect of society.
The upshot is another piece of evidence of how, around this period, humans were
  creating a range of hitherto unknown artefacts.
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