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arthus reaction

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Ar⋅thus' reac⋅tion

[ahr-too-siz]
–noun Immunology.
a severe, local immune reaction to the injection of an antigen in a sensitized host.
Also called Arthus' phenomenon.


Origin:
after Nicolas-Maurice Arthus (1862–1945), French physiologist, who discovered it in 1903
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Based on the Random House Dictionary, © Random House, Inc. 2009.
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Medical Dictionary

Main Entry: Ar·thus reaction
Pronunciation: 'är-th&s-, or-'t[UE]s-
Function: noun
: a reaction that follows injection of an antigen into ananimal in which hypersensitivity has been previously established and that involves infiltrations, edema, sterile abscesses, and in severe cases gangrene called also Arthus phenomenon
Aráthus /or-t[UE]s/,Nicolas Maurice (1862–1945), French bacteriologist and physiologist. Arthus was primarily concerned with venoms and antivenins and withcoagulability and anticoagulants. In 1890 he published an article on coagulation that demonstrated for the first time the essential role of calcium in blood coagulation. In 1903, in an articlereporting a study involving repeated injections of horse serum into rabbits, he reported discovery of the phenomenon of local anaphylaxis, a phenomenon that has since become identified with his name.
Merriam-Webster's Medical Dictionary, © 2002 Merriam-Webster, Inc.
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