"You canker blossom!" 3 Shakespearean Insults
1610s, from Latin astutus "crafty, wary, shrewd; sagacious, expert," from astus "cunning, cleverness, adroitness," of uncertain origin, perhaps from Greek asty "town," a word borrowed into Latin and with an overtone of "city sophistication" (cf. asteism). Related: Astutely; astuteness.