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[ath-uh-roh-skluh-roh-sis, ath-] /ˌæθ ə roʊ skləˈroʊ sɪs, ˌæð-/
noun, Pathology
a common form of arteriosclerosis in which fatty substances form a deposit of plaque on the inner lining of arterial walls.
1905-10; < German Atherosklerose; see athero-, sclerosis
Related forms
[ath-uh-roh-skluh-rot-ik, ath-] /ˌæθ ə roʊ skləˈrɒt ɪk, ˌæð-/ (Show IPA),
atherosclerotically, adverb Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2015.
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British Dictionary definitions for atheroscleroses


noun (pl) -ses (-siːz)
a degenerative disease of the arteries characterized by patchy thickening of the inner lining of the arterial walls, caused by deposits of fatty material; a form of arteriosclerosis See atheroma
Derived Forms
atherosclerotic (ˌæθərəʊsklɪəˈrɒtɪk) adjective
Word Origin
C20: from New Latin, from Greek athēra gruel (see atheroma) + sclerosis
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin and History for atheroscleroses



1908, from atherosklerose, coined in German 1904; see atheroma + sclerosis.

Online Etymology Dictionary, © 2010 Douglas Harper
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atheroscleroses in Medicine

atherosclerosis ath·er·o·scle·ro·sis (āth'ə-rō-sklə-rō'sĭs)
A form of arteriosclerosis characterized by the deposition of atheromatous plaques containing cholesterol and lipids on the innermost layer of the walls of large and medium-sized arteries.

ath'er·o·scle·rot'ic (-rŏt'ĭk) adj.
The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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atheroscleroses in Science

A form of arteriosclerosis characterized by the deposition of plaques containing cholesterol and lipids on the innermost layer of the walls of large- and medium-sized arteries. Individuals with atherosclerosis have a higher risk of coronary artery disease and stroke. Smoking, high blood pressure, diabetes mellitus, and elevated levels of fat in the blood contribute to the development of atherosclerosis.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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atheroscleroses in Culture
atherosclerosis [(ath-uh-roh-skluh-roh-sis)]

A form of arteriosclerosis in which the arteries become clogged by the buildup of fatty substances, which eventually reduces the flow of blood to the tissues. These fatty substances, called plaque, are made up largely of cholesterol. (Compare arteriosclerosis; see circulatory system.)

The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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Encyclopedia Article for atheroscleroses


chronic disease caused by the deposition of fats, cholesterol, calcium, and other substances in the innermost layer of endothelium of the large and medium-sized arteries. Atherosclerosis is the most common arterial abnormality characterized as arteriosclerosis, which is defined by the loss of arterial elasticity due to vessel thickening and stiffening. The precise mechanisms of atherosclerosis are not completely understood, but there is evidence that in some people the condition can begin in childhood with the formation of tiny "fatty streaks," or streaks of fat deposition, in the arteries. As the endothelium is infiltrated by more and more fatty materials-primarily low-density lipoproteins (LDLs), protein-lipid complexes that serve as a vehicle for delivering cholesterol to the body-immune cells called macrophages are drawn to the site to scavenge the materials. When filled with lipids the macrophages become known as "foam cells," which later die and accumulate in the endothelial lining. Other materials are also deposited in the lining, including salts of calcium and other minerals, smooth muscle cells, and cellular debris of varying composition. This causes the initially tiny lesions to enlarge and thicken to form atheromas, or atherosclerotic plaques. These plaques may narrow the vessel channel, interfering with the flow of blood. Endothelial injury, either as a result of lipid deposition or as a result of another cause, may also be accompanied by the formation of fibrous caps of scar tissue. These areas of scar tissue make the vessel walls less elastic, with one consequence being an increase in blood pressure. Thick plaques that severely occlude an artery can significantly decrease the flow of blood to vascular beds in tissues served by the artery, thereby causing severe tissue damage. In addition, a disturbance to the endothelium may result in the formation of a blood clot (thrombus) at the site of a plaque, likewise obstructing the channel or breaking loose from the site and causing a catastrophic blockage elsewhere.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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