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azathioprine

[az-uh-thahy-uh-preen] /ˌæz əˈθaɪ əˌprin/
noun, Pharmacology
1.
a cytotoxic purine analog, C 9 H 7 N 7 O 2 S, used as an immunosuppressive in organ transplantations and in rheumatoid arthritis and connective tissue disorders.
Origin
1960-1965
1960-65; coinage apparently based on imidazol, thio-, and purine, parts of the chemical name
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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Examples from the web for azathioprine
  • Allopurinol interacts with certain other drugs, such as azathioprine.
British Dictionary definitions for azathioprine

azathioprine

/ˌæzəˈθaɪəˌpriːn/
noun
1.
a synthetic drug that suppresses the normal immune responses of the body and is administered orally during and after organ transplantation and also in certain types of autoimmune disease. Formula: C9H7N7O2S
Word Origin
C20: from aza- + thio- + p(u)rine
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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azathioprine in Medicine

azathioprine az·a·thi·o·prine (āz'ə-thī'ə-prēn')
n.
An immunosuppressive agent used especially to prevent organ rejection in kidney transplant recipients.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Article for azathioprine

immunosuppressive drug that is used to treat rheumatoid arthritis and to suppress the body's rejection of transplanted organs. By inhibiting several enzymatic pathways required for the synthesis of deoxyribonucleic acid (DNA), azathioprine decreases the number of lymphocytes (a type of white blood cell) that can migrate to inflammatory sites. Leukopenia (an abnormally low number of white blood cells in the circulation) is the major undesirable side effect of the drug, although anemia and hemorrhage may also occur. When used with allopurinol, the pharmacological effect of azathioprine is increased.

Learn more about azathioprine with a free trial on Britannica.com
Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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