the blood flowing through a circulatory system.

1870–75; blood + stream Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
bloodstream (ˈblʌdˌstriːm)
the flow of blood through the vessels of a living body

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

1873, from blood + stream.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

bloodstream blood·stream (blŭd'strēm')
The flow of blood through the circulatory system of an organism.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Typically, a couple of dozen slip into the bloodstream.
Once inside the body, the parasites enter the bloodstream and are quickly
  carried to the liver.
Nano-size sensors placed in the bloodstream could better detect early onset of
  diseases, for example.
Inhaling smoke from a crack pipe enables the cocaine to be absorbed into the
  bloodstream as rapidly as it would be if injected.
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