cholecystoduodenostomy cho·le·cys·to·du·o·de·nos·to·my (kō'lĭ-sĭs'tō-d&oomacr;'ə-dn-ŏs'tə-mē, -dy&oomacr;'-, -d&oomacr;-ŏd'n-ŏs'-, -dy&oomacr;-) n. The surgical formation of a communication between the gallbladder and the duodenum.