clinical depression

noun
Psychiatry. a depression so severe as to be considered abnormal, either because of no obvious environmental causes, or because the reaction to unfortunate life circumstances is more intense or prolonged than would generally be expected.
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Based on the Random House Dictionary, © Random House, Inc. 2014.
Cite This Source Link To clinical depression
Example sentences
Whether he suffered from a full-blown case of what today is called clinical
  depression is unknown.
My husband was suffering from clinical depression and attempted to take his own
  life three years ago.
Parental reports of depressive symptoms are not the same as, and not indicative
  of, clinical depression.
The process literally plunged me into a bout with clinical depression.
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