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1755, from Latinized form of Greek komat-, comb. form of koma (genitive komatos; see coma) + -ose (1). Perhaps immediately from French comateux. Transferred sense of "lethargic" is from 1828.
comatose co·ma·tose (kō'mə-tōs', kŏm'ə-)adj.
Of, relating to, or affected with coma.
Marked by lethargy; torpid.