the act of complicating.
a complicated or involved state or condition.
a complex combination of elements or things.
something that introduces, usually unexpectedly, some difficulty, problem, change, etc.: Because of the complications involved in traveling during the strike, we decided to postpone our trip.
Pathology. a concurrent disease, accident, or adverse reaction that aggravates the original disease.
the act of forming a unified idea or impression from a number of sense data, memories, etc.

1605–15; < Late Latin complicātīon- (stem of complicātiō), equivalent to complicāt(us) (see complicate) + -īon- -ion

complicative, adjective
precomplication, noun
recomplication, noun

4. drawback, handicap, obstacle. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
complication (ˌkɒmplɪˈkeɪʃən)
1.  a condition, event, etc, that is complex or confused
2.  the act or process of complicating
3.  a situation, event, or condition that complicates or frustrates: her coming was a serious complication
4.  a disease or disorder arising as a consequence of another disease

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

1611, from M.Fr. complication, from L. complicationem, from complicare "to fold together," from com- "together" + plicare "to fold, weave" (see ply (v.)). Meaning "something that complicates" first recorded 1903.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

complication com·pli·ca·tion (kŏm'plĭ-kā'shən)
A pathological process or event occurring during a disease that is not an essential part of the disease; it may result from the disease or from independent causes.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
The cause was a pulmonary embolism as a complication of lung cancer, his family
The increase in the strength and frequency of hurricanes is a complication of
  the greenhouse effect.
One has to applaud the genius of a city that provides not only a complication
  but its resolution.
Lotus says paddle shifters add dead weight and needless complication.
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