the act of complicating.
a complicated or involved state or condition.
a complex combination of elements or things.
something that introduces, usually unexpectedly, some difficulty, problem, change, etc.: Because of the complications involved in traveling during the strike, we decided to postpone our trip.
Pathology. a concurrent disease, accident, or adverse reaction that aggravates the original disease.
the act of forming a unified idea or impression from a number of sense data, memories, etc.

1605–15; < Late Latin complicātīon- (stem of complicātiō), equivalent to complicāt(us) (see complicate) + -īon- -ion

complicative, adjective
precomplication, noun
recomplication, noun

4. drawback, handicap, obstacle. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
complication (ˌkɒmplɪˈkeɪʃən)
1.  a condition, event, etc, that is complex or confused
2.  the act or process of complicating
3.  a situation, event, or condition that complicates or frustrates: her coming was a serious complication
4.  a disease or disorder arising as a consequence of another disease

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

1611, from M.Fr. complication, from L. complicationem, from complicare "to fold together," from com- "together" + plicare "to fold, weave" (see ply (v.)). Meaning "something that complicates" first recorded 1903.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

complication com·pli·ca·tion (kŏm'plĭ-kā'shən)
A pathological process or event occurring during a disease that is not an essential part of the disease; it may result from the disease or from independent causes.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Researchers have found that unproven stem cell treatments can also cause
  complications for patients.
The patient recovered without complications and went home two days later,
  according to the medical team.
Another had complications from being born prematurely.
Historically, administrative complications have been a major culprit.
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