| constant region n. The portion of the carboxyl terminal of an immunoglobulin's heavy and light chains having an amino acid sequence that does not vary within a given class or subclass of immunoglobulin. |
| constant region
The portion of the amino acid sequence of an antibody's heavy or light chains that determines the class of the antibody and does not vary within a given class. The constant region terminates in a free carboxyl group (COOH). Unlike the variable region, the constant region does not interact with antigens. Compare variable region. |