controlled substance

noun
any of a category of behavior-altering or addictive drugs, as heroin or cocaine, whose possession and use are restricted by law.

Origin:
1970–75

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Based on the Random House Dictionary, © Random House, Inc. 2014.
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American Heritage
Medical Dictionary

controlled substance n.
A drug or chemical substance whose possession and use are regulated under the Controlled Substances Act.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
If controlled substance testing was against the law there wouldn't be any
  pharmaceutical drugs.
The defendant shall not unlawfully possess a controlled substance.
Our position is that it should remain a controlled substance.
He was cited for suspicion of being under the influence of a controlled
  substance.
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