|Creutzfeldt-Jakob disease (ˈkrɔɪtsfɛlt ˈjɑːkɒp)|
|pathol a fatal slow-developing disease that affects the central nervous system, characterized by mental deterioration and loss of coordination of the limbs. It is thought to be caused by an abnormal prion protein in the brain|
|[C20: named after Hans G. Creutzfeldt (1885--1964) and Alfons Jakob (1884--1931), German physicians]|
|Creutzfeldt-Jakob disease (kroits'fělt-yä'kôp) Pronunciation Key
A rare, usually fatal encephalopathy that occurs most often in middle age and is likely caused by a prion. It is characterized by progressive dementia and gradual loss of muscle control. The disease is named after its discoverers, German pathologist Hans Gerhard Creutzfeldt (1885-1964) and German neurologist Alfons Maria Jakob (1884-1931).