"You canker blossom!" 3 Shakespearean Insults
1540s, first element obscure, second element is Northumbrian or East Anglian dialectal huff, hurf "scab," from Old Norse hrufa, from Proto-Germanic *hreufaz, source of Old English hreofla "leper."
dandruff dan·druff (dān'drəf)
A scaly scurf formed on and shed from the scalp.