Obsolete. to anger or annoy (someone) out of spite.
in despite of, in spite of; notwithstanding: He was tolerant in despite of his background and education.
Origin: 1250–1300; orig. in despite of;Middle Englishdespit < Old French < Latindēspectus view from a height, scorn, equivalent to dēspec-, variant stem of dēspicere (see despicable) + -tus suffix of v. action
c.1300, from O.Fr. despit, from L. despectus "a looking down on," from despicere (see despise). The preposition (1593) is short for in despite of (1292), a loan-translation of Fr. en despit de "in contempt of." Almost became despight during 16c. spelling reform.