verb (used with object), depleted, depleting.
to decrease seriously or exhaust the abundance or supply of: The fire had depleted the game in the forest. Extravagant spending soon depleted his funds.

1800–10; < Latin dēplētus empty (past participle of dēplēre to empty out), equivalent to dē- de- + plē(re) to fill + -tus past participle suffix

depletable, adjective
depletion, noun
depletive, depletory [dih-plee-tuh-ree] , adjective
nondepletable, adjective
nondepletion, noun
nondepletive, adjective
nondepletory, adjective
predeplete, verb (used with object), predepleted, predepleting.
predepletion, noun
undepleted, adjective

use up, drain, reduce, consume, lessen. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
deplete (dɪˈpliːt)
1.  to use up (supplies, money, energy, etc); reduce or exhaust
2.  to empty entirely or partially
3.  med to empty or reduce the fluid contents of (an organ or vessel)
[C19: from Latin dēplēre to empty out, from de- + plēre to fill]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

1650s, from L.L. depletionem (nom. depletio) "blood-letting," from L. deplere "to empty," lit. "to un-fill," from de- "off, away" + plere "to fill" (see plenary).

1807, back-formation from depletion. Related: Depleted; depleting.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

deplete de·plete (dĭ-plēt')
v. de·plet·ed, de·plet·ing, de·pletes

  1. To use up something, such as a nutrient.

  2. To empty something out, as the body of electrolytes.

depletion de·ple·tion (dĭ-plē'shən)

  1. The act or process of depleting.

  2. The state of being depleted; exhaustion.

  3. Removal of or reduction in a body substance, such as blood, a fluid, or a nutrient.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Increases in skin cancer cases have been recorded in parallel with ozone
Depletion of large predatory fish disrupts food chain.
Both areas have lost species because of the depletion of the water supply and
  agricultural expansion.
That, along with fraud carried out by some doctors, has contributed to the
  depletion of the insurance fund.
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