derail

[dee-reyl]
verb (used with object)
1.
to cause (a train, streetcar, etc.) to run off the rails of a track.
2.
to cause to fail or become deflected from a purpose; reduce or delay the chances for success or development of: Being drafted into the army derailed his career for two years.
verb (used without object)
3.
(of a train, streetcar, etc.) to run off the rails of a track.
4.
to become derailed; go astray.
noun
5.
a track device for derailing rolling stock in an emergency.

Origin:
1840–50; < French dérailler, equivalent to dé- dis-1 + -railler, verbal derivative of rail rail1 (< E)

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Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
derail (dɪˈreɪl)
 
vb
1.  to go or cause to go off the rails, as a train, tram, etc
 
n
2.  chiefly (US) Also called: derailer a device designed to make rolling stock or locomotives leave the rails to avoid a collision or accident
 
de'railment
 
n

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Etymonline
Word Origin & History

derail
1850, in both trans. and intrans. senses, from Fr. dérailler "to go off the rails," from de- + railler (see rail). In general use first in U.S.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
The insider was profoundly disappointed and left to wonder what had derailed
  his candidacy.
For example, your entire digital humanities project could be derailed by a
  server failure.
Not that quick, and obviously could be derailed by any number of factors, but
  well within the range of many animals and plants.
The duo worked with several major labels over the years, but those deals all
  derailed.
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