verb (used with object), deranged, deranging.
to throw into disorder; disarrange.
to disturb the condition, action, or function of.
to make insane.

1770–80; < French déranger, Old French desrengier, equivalent to des- dis-1 + rengier; see range

derangeable, adjective
deranger, noun Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
derange (dɪˈreɪndʒ)
1.  to disturb the order or arrangement of; throw into disorder; disarrange
2.  to disturb the action or operation of
3.  to make insane; drive mad
[C18: from Old French desrengier, from des-dis-1 + reng row, order]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

1776, from Fr. déranger, from O.Fr. desrengier "disarrange," from des- "do the opposite of" + reng "line, row" (see rank). Mental sense first recorded c.1790.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Inadequate folate intake can also derange biological methylation pathways.
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