preposition, noun, verb, -spit⋅ed, -spit⋅ing.| 1. | in spite of; notwithstanding. |
| 2. | contemptuous treatment; insult. |
| 3. | malice, hatred, or spite. |
| 4. | Obsolete. to anger or annoy (someone) out of spite. |
| 5. | in despite of, in spite of; notwithstanding: He was tolerant in despite of his background and education. |
