discombobulate

[dis-kuhm-bob-yuh-leyt]
verb (used with object), discombobulated, discombobulating.
to confuse or disconcert; upset; frustrate: The speaker was completely discombobulated by the hecklers.

Origin:
1825–35, Americanism; fanciful alteration of discompose or discomfort

discombobulation, noun
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World English Dictionary
discombobulate (ˌdɪskəmˈbɒbjʊˌleɪt)
 
vb
informal chiefly (US), (Canadian) (tr) to throw into confusion
 
[C20: probably a whimsical alteration of discompose or discomfit]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Etymonline
Word Origin & History

discombobulate
1834, Amer.Eng., fanciful coinage of a type popular then (originally discombobricate). Related: discombobulating; discombobulation.

discombobulated
1834 (as discombobracated); see discombobulate.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
But I'm a bit discombobulated by the latest development.
That seemingly innocuous question has totally discombobulated you and forced
  you to re-examine what it is you are doing and why.
The really bad ones always leave me discombobulated.
The studio's executives seem a bit discombobulated by all the fuss.
Synonyms
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