disquietude

[dis-kwahy-i-tood, -tyood]
noun
the state of disquiet; uneasiness.

Origin:
1700–10; dis-1 + quietude

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World English Dictionary
disquietude (dɪsˈkwaɪɪˌtjuːd)
 
n
a feeling or state of anxiety or uneasiness

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Etymonline
Word Origin & History

disquietude
1709, from dis- + quietude.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Yet, despite the beauty of the scene, a strange sense of disquietude pervades these photographs.
The similarities in result are striking enough to engender a feeling either of helpless disquietude, or defensive disbelief.
He complains of severe pains in the head, and general disquietude.
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