| a genetic disorder, associated with the presence of an extra chromosome 21, characterized by mild to severe mental retardation, weak muscle tone, a low nasal bridge, and epicanthic folds at the eyelids. |

Down's syndrome (dounz) n. Variant of Down syndrome. |
A congenital condition, caused by an abnormality in the chromosomes, marked by moderate to severe mental retardation and changes in certain physical features.
Down syndrome (doun) or Down's syndrome (dounz)
n.
A congenital disorder, caused by the presence of an extra 21st chromosome, in which the affected person has mild to moderate mental retardation, short stature, and a flattened facial profile. Also called trisomy 21, trisomy 21 syndrome.
| Down syndrome (doun) or Down's Syndrome (doun) Pronunciation Key
A congenital disorder caused by the presence of an extra 21st chromosome. People with Down syndrome have mild to moderate mental retardation, short stature, and a flattened facial profile. The syndrome is named after its discoverer, British physician John Langdon Haydon Down (1828-1896). |