late 14c. (early 14c. in Anglo-French), "medicine, chemical ingredients," from Old French droge "supply, stock, provision" (14c.), of unknown origin, perhaps from Middle Dutch or Middle Low German droge-vate "dry barrels," or droge waere, literally "dry wares," but specifically drugs and spices, with first element mistaken as word for the contents (see dry goods), or because medicines mostly consisted of dried herbs.
Cf. Latin species, in Late Latin "wares," then specialized to "spices" (French épice, English spice). The same source produced Italian and Spanish droga, Swedish drog.
Application to "narcotics and opiates" is late 19c., though association with "poisons" is 1500s. Druggie first recorded 1968. To be a drug on or in the market (mid-17c.) is of doubtful connection and may be a different word, perhaps a play on drag, which was sometimes drug c.1240-1800.
c.1600, from drug (n.). Related: drugged; drugging.
A substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication.
Such a substance as recognized or defined by the U.S. Food and Drug Administration.
A chemical substance, such as a narcotic or hallucinogen, that affects the central nervous system, causing changes in behavior and often addiction.
To administer a drug, especially in an overly large quantity, to an individual.
To stupefy or dull with or as if with a drug; to narcotize.
Displeased; angry; pissed off: If other players are drug about it or feel that I'm trying to horn in, then it's not much fun
[1940+ Jazz musicians; past participle of drag, in a dialect variation]