duodenojejunal flexure du·o·de·no·je·ju·nal flexure (d&oomacr;'ə-dē'nō-jə-j&oomacr;'nəl, dy&oomacr;'-, d&oomacr;-ŏd'n-ō-, dy&oomacr;-) n. An abrupt bend in the small intestine at the junction of the duodenum and jejunum.