duodenolysis du·o·de·nol·y·sis (d&oomacr;'ō-dn-ŏl'ĭ-sĭs, dy&oomacr;'-, d&oomacr;-ŏd'n-ŏl'-, dy&oomacr;-) n. The freeing of the duodenum from adhesions by means of surgery.