duodenoscopy du·o·de·nos·co·py (d&oomacr;'ə-dn-ŏs'kə-pē, dy&oomacr;'-, d&oomacr;-ŏd'n-ŏs'-, dy&oomacr;-) n. The examination of the interior of the duodenum through an endoscope.