ech·o·en·ceph·a·lo·graph (ěk'ō-ěn-sěf'ə-lə-grāf', -ə-lō-) n. An instrument that in a painless and noninvasive manner uses the differential transmission and reflection of ultrasonic waves to create a detailed visual image of the brain. ech'o·en·ceph'a·lo·graph'ic adj., ech'o·en·ceph'a·log'ra·phy (-lŏg'rə-fē) n.