encephalomyeloneuropathy en·ceph·a·lo·my·e·lo·neu·rop·a·thy (ěn-sěf'ə-lō-mī'ə-lō-n&oobreve;-rŏp'ə-thē, -ny&oobreve;-) n. Any of various diseases involving the brain, spinal cord, and peripheral nervous system.