[en-doh-noo-klee-eys, -eyz, -nyoo-]
noun Biochemistry.
any of a group of enzymes that degrade DNA or RNA molecules by breaking linkages within the polynucleotide chains.

1960–65; endo- + nuclease

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World English Dictionary
endonuclease (ˌɛndəʊˈnjuːklɪˌeɪz)
Compare exonuclease an enzyme that is responsible for scission of a nucleic acid chain, the action of which is not confined to the terminal nucleotide

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Medical Dictionary

endonuclease en·do·nu·cle·ase (ěn'dō-nōō'klē-ās', -āz', -nyōō'-)
Any of a group of enzymes that catalyze the hydrolysis of phosphodiester bonds between nucleic acids in a DNA molecule or an RNA sequence.

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